Evaluation of risk factors for oral infection with potential for spread in a 1-year cohort study

Objectives To determine the frequency of oral infection with potential for spread (OIPS) and behavioural risk factors in patients referred to a regional tertiary care-centre for OIPS assessment and clearance. Materials and methods A database search of all referrals to the Oral and Maxillofacial Diseases unit of HUH in 2009 was performed. Of the 2807 referrals, 408 were due to a known or suspected OIPS. The electronic patient records of these patients were analysed for patient demographics, lifestyle factors, radiological findings and clinical oral findings. Risk factors for OIPS were analysed using logistic regression and using the significant factors in univariate analyses in the multivariate models. Results The mean age of the patients was 58 years. Most patients ( n = 270, 66%) were referred due to upcoming cancer or other immunosuppressive therapy. The majority ( n = 314, 77%) were diagnosed with one or more OIPS. In univariate analyses, smoking (OR 3.2, 95% CI 1.6–6.4; p = 0.0006), male gender (OR 1.7, 95% CI 1.1–2.8; p = 0.02), excessive alcohol use (OR 3.0, 95% 1.1–7.9; p = 0.03) and irregular dental care (OR 4.8, 95% CI 2.6–8.8; p