Brief communication: A myeloproliferative disorder may hide another one

Chronic myeloproliferative disorders (MPDs) are divided into Philadelphia-positive chronic myeloid leukemia (CML) and Philadelphia-negative disorders including polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis (IMF). Concomitance of a CML and another MPD is a rare event. We r...

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Veröffentlicht in:Leukemia research 2009-08, Vol.33 (8), p.1133-1136
Hauptverfasser: Laibe, Sophy, Tadrist, Zoulika, Arnoulet, Christine, Sainty, Danielle, Mozziconacci, Marie-Joelle
Format: Artikel
Sprache:eng
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Zusammenfassung:Chronic myeloproliferative disorders (MPDs) are divided into Philadelphia-positive chronic myeloid leukemia (CML) and Philadelphia-negative disorders including polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis (IMF). Concomitance of a CML and another MPD is a rare event. We report here the case of a patient presenting initially with IMF who developed a Philadelphia-positive CML 7 years later. At the time of CML diagnosis, two distinct clones were present, one with a 13q deletion and one with a t(9; 22). We raise the problem of a CML developing on an initial IMF, or two MPDs occurring from a common or two different stem cells.
ISSN:0145-2126
DOI:10.1016/j.leukres.2009.01.034