MDMA: On the translation from rodent to human dosing

MDMA: On the translation from rodent to human dosing

Future preclinical pharmacological research on MDMA should be linked much more closely to appropriate exposure analysis coupled to parent compound and potentially neurotoxic metabolite(s), in order that informed extrapolation may be made as to the likely acute and long-term effects of this popular r...

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Veröffentlicht in:Psychopharmacology 2009-06, Vol.204 (2), p.375-378
Hauptverfasser: Green, A. Richard, Gabrielsson, Johan, Marsden, Charles A., Fone, Kevin C. F.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biomedical and Life Sciences
Biomedicine
Commentary
Dose-Response Relationship, Drug
Drug addiction
Drug dosages
Hallucinogens - administration & dosage
Hallucinogens - pharmacokinetics
Hallucinogens - pharmacology
Humans
Methamphetamine
N-Methyl-3,4-methylenedioxyamphetamine - administration & dosage
N-Methyl-3,4-methylenedioxyamphetamine - pharmacokinetics
N-Methyl-3,4-methylenedioxyamphetamine - pharmacology
Neurosciences
Pharmacology/Toxicology
Psychiatry
Psychopharmacology
Rats
Rodents
Species Specificity
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Beschreibung
Zusammenfassung:Future preclinical pharmacological research on MDMA should be linked much more closely to appropriate exposure analysis coupled to parent compound and potentially neurotoxic metabolite(s), in order that informed extrapolation may be made as to the likely acute and long-term effects of this popular recreational drug in human users.
ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-008-1453-8