Proliferative and osteogenic differentiation capacity of mesenchymal stromal cells: Influence of harvesting site and donor age

Human mesenchymal stromal cells (hMSCs) are the cellular source of new bone formation and an essential component of autologous bone grafts. Autologous bone graft harvesting is routinely conducted at the iliac crest, although alternative donor sites with lower complication rates are available. Thus,...

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Veröffentlicht in:	Injury 2018-08, Vol.49 (8), p.1504-1512
Hauptverfasser:	Prall, Wolf Christian, Saller, Maximilian Michael, Scheumaier, Anna, Tucholski, Timo, Taha, Sara, Böcker, Wolfgang, Polzer, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Autologous bone graft Bone Morphogenetic Protein 2 - metabolism Cell Differentiation - physiology Cell Proliferation - physiology Cells, Cultured Donor site Female Human mesenchymal stromal cell Humans Iliac crest Ilium - transplantation Male Mesenchymal Stem Cells - cytology Middle Aged Osteogenesis - physiology Osteogenic differentiation Proliferation Proximal tibia Tibia - transplantation Tissue and Organ Harvesting - methods Tissue Donors Transplantation, Autologous - methods Young Adult
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