Crown-capped imidacloprid: A novel design and insecticidal activity

Benzocrown-capped imidacloprid displayed higher insecticidal activity than imidacloprid. Imidacloprid (IMI) derivatives conjugated with benzo-15-crown-5 and benzo-18-crown-6 structures, applied for the first time to explore novel insecticidal molecule, elicited strong excitatory toxic signs to the h...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-06, Vol.19 (11), p.2947-2948
Hauptverfasser:	Kagabu, Shinzo, Takagi, Masaru, Ohno, Ikuya, Mikawa, Tsuyoshi, Miyamoto, Toru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chemical control Control Crown Ethers - chemistry Crown-capped insecticide Drug Design Female Fundamental and applied biological sciences. Psychology Houseflies - drug effects Imidacloprid Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology Insecticides - chemical synthesis Insecticides - chemistry Insecticides - pharmacology Neonicotinoid insecticides Neonicotinoids Nitro Compounds - chemical synthesis Nitro Compounds - chemistry Nitro Compounds - pharmacology Phytopathology. Animal pests. Plant and forest protection Protozoa. Invertebrates
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Zusammenfassung:	Benzocrown-capped imidacloprid displayed higher insecticidal activity than imidacloprid. Imidacloprid (IMI) derivatives conjugated with benzo-15-crown-5 and benzo-18-crown-6 structures, applied for the first time to explore novel insecticidal molecule, elicited strong excitatory toxic signs to the house flies and stunningly exhibited three to five times higher insecticidal activity than that of the parent IMI, yet the two benzo-crown structures themselves had no effect.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2009.04.053