HDAC6 at Crossroads of Infection and Innate Immunity

HDAC6 at Crossroads of Infection and Innate Immunity

Histone deacetylase 6 (HDAC6) acts by enzyme-dependent and -independent mechanisms to regulate diverse cellular processes including autophagy, the ubiquitin proteasome system, and cell migration. HDAC6 also has emerging roles in innate immunity, including pathogen sensing and destruction, thus placi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Trends in immunology 2018-08, Vol.39 (8), p.591-595
Hauptverfasser: Moreno-Gonzalo, Olga, Mayor, Federico, Sánchez-Madrid, Francisco
Format: Artikel
Sprache:eng
Schlagworte:
Autophagy
bacterial and viral infection
Bacterial infections
Cell migration
Cytokines
deacetylase
HDAC6
Histone deacetylase
Infections
inflammation
Innate immunity
Kinases
Nitric oxide
Phagocytosis
Proteasomes
Proteins
Rodents
Sepsis
Ubiquitin
Viral infections
Viruses
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Histone deacetylase 6 (HDAC6) acts by enzyme-dependent and -independent mechanisms to regulate diverse cellular processes including autophagy, the ubiquitin proteasome system, and cell migration. HDAC6 also has emerging roles in innate immunity, including pathogen sensing and destruction, thus placing this enzyme at the crossroads of infection and innate immunity.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2018.05.004