Shaping molecular diversity

Shaping molecular diversity

Certain drug targets have been deemed undruggable because of the difficulty in finding pharmacologically useful inhibitors. Now, two teams have developed exciting technologies for the creation of diverse collections of macrocyclic molecules and have demonstrated their usefulness for discovering macr...

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Veröffentlicht in:Nature chemistry 2018-07, Vol.10 (7), p.692-694
Hauptverfasser: Iqbal, Emil S., Hartman, Matthew C. T.
Format: Artikel
Sprache:eng
Schlagworte:
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639/638/92/2132
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Analytical Chemistry
Biochemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inhibitors
Inorganic Chemistry
Molecular chains
News & Views
news-and-views
Organic Chemistry
Pharmacology
Physical Chemistry
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Beschreibung
Zusammenfassung:Certain drug targets have been deemed undruggable because of the difficulty in finding pharmacologically useful inhibitors. Now, two teams have developed exciting technologies for the creation of diverse collections of macrocyclic molecules and have demonstrated their usefulness for discovering macrocyclic inhibitors.
ISSN:1755-4330
1755-4349
DOI:10.1038/s41557-018-0095-7