In vivo evidence that the cannabinoid receptor 2–63 RR variant is associated with the acquisition and/or expansion of HIV infection

In vivo evidence that the cannabinoid receptor 2–63 RR variant is associated with the acquisition and/or expansion of HIV infection

Objectives The aim of the study was to investigate whether the rs35761398 variants of the cannabinoid receptor 2 (CB2) gene may influence the acquisition of HIV infection and the clinical presentation of HIV/hepatitis C virus (HCV) coinfection. Methods We compared 166 HIV/HCV‐coinfected patients wit...

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Veröffentlicht in:HIV medicine 2018-10, Vol.19 (9), p.597-604
Hauptverfasser: Sagnelli, C, Uberti‐Foppa, C, Hasson, H, Bellini, G, Minichini, C, Salpietro, S, Messina, E, Barbanotti, D, Merli, M, Punzo, F, Coppola, N, Lazzarin, A, Sagnelli, E, Rossi, F
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Alanine
Alanine transaminase
Aspartate aminotransferase
Biopsy
Body mass
Body mass index
Body size
Cannabinoid CB2 receptors
cannabinoid receptor
cannabinoid receptor 2
Coinfection - epidemiology
Cross-Sectional Studies
endocannabinoids
Female
Genetic Predisposition to Disease
Hepatitis
Hepatitis C
Hepatitis C - epidemiology
Hepatitis C - genetics
Hepatitis C - metabolism
HIV
HIV Infections - epidemiology
HIV Infections - genetics
HIV Infections - metabolism
HIV/hepatitis C virus coinfection
Human immunodeficiency virus
Humans
Infections
Liver
liver biopsy
liver histology
liver steatosis
Male
Middle Aged
Patients
Polymorphism
Polymorphism, Single Nucleotide
Receptor, Cannabinoid, CB2 - genetics
Ribonucleic acid
RNA
Sexual and Gender Minorities - classification
Sexually transmitted diseases
STD
Steatosis
Variance analysis
Viruses
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Zusammenfassung:Objectives The aim of the study was to investigate whether the rs35761398 variants of the cannabinoid receptor 2 (CB2) gene may influence the acquisition of HIV infection and the clinical presentation of HIV/hepatitis C virus (HCV) coinfection. Methods We compared 166 HIV/HCV‐coinfected patients with 186 HCV‐monoinfected patients, all with biopsy‐proven chronic hepatitis (using the Ishak scoring system), naïve for anti‐HCV treatment and tested for the CB2 rs35761398 polymorphism (using the TaqMan assay). Results The HIV/HCV‐coinfected patients were more frequently male (P 
ISSN:1464-2662
1468-1293
DOI:10.1111/hiv.12638