Lower circulating levels of angiotensin-converting enzyme (ACE) in patients with schizophrenia

Lower circulating levels of angiotensin-converting enzyme (ACE) in patients with schizophrenia

This study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1–7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Pat...

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Veröffentlicht in:Schizophrenia research 2018-12, Vol.202, p.50-54
Hauptverfasser: Mohite, Satyajit, de Campos-Carli, Salvina M., Rocha, Natalia P., Sharma, Shiva, Miranda, Aline S., Barbosa, Izabela G., Salgado, Joao V., Simoes-e-Silva, Ana Cristina, Teixeira, Antonio L.
Format: Artikel
Sprache:eng
Schlagworte:
Angiotensin
Angiotensin-converting enzyme
Cognition
Renin-angiotensin system (RAS)
Schizophrenia
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Zusammenfassung:This study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1–7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th–75th percentiles) = 434.79 (341.15–524.02) vs. 508.49 (396.34–608.72); p 
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2018.06.023