Toxicologic Interaction of Potassium Bromate and Allium cepa, Allium sativum or Sodium Selenite in Wistar Rats

Although diets containing mixtures of 600 mg kg super(-1) of KBrO sub(3) plus 2% Allium sativum, 600 mg kg super(-1) KBrO sub(3) plus 2% Allium cepa and 600 mg kg super(-1) of KBrO sub(3) plus 1 mg kg super(-1) sodium selenite did not adversely affect the growth of Wistar rats, a significant decrease in body weight gain, hepatonephropathy, desquamation of the intestinal epithelium into the lumen and lymphocytic accumulation in vital organs were observed in the rats fed a diet consisting of 600 mg kg super(-1) of KBrO sub(3) singly for 4 weeks. These changes associated with macrocytic normochromic anemia were correlated with alterations in serum aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) activities and concentrations of cholesterol, urea and other serum constituents. However, none of the rats died during the 4-week period.