Complete response of deep neutrophilic dermatosis associated with myelodysplastic syndrome to 5‐azacytidine
Summary Cutaneous manifestations of myelodysplastic syndromes (MDS) may predict disease progression and a poorer prognosis. We describe a patient in whom a deep neutrophilic dermatosis preceded evolution of disease from refractory anaemia to RAEB (refractory anaemia with excess blasts) and resolved...
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| Veröffentlicht in: | British journal of dermatology (1951) 2007-05, Vol.156 (5), p.1039-1041 |
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| container_title | British journal of dermatology (1951) |
| container_volume | 156 |
| creator | Raj, K. Ho, A. Creamer, J.D. Du Vivier, A.W.P. Salisbury, J.R. Mufti, G.J. |
| description | Summary Cutaneous manifestations of myelodysplastic syndromes (MDS) may predict disease progression and a poorer prognosis. We describe a patient in whom a deep neutrophilic dermatosis preceded evolution of disease from refractory anaemia to RAEB (refractory anaemia with excess blasts) and resolved completely on treating the disease with 5‐azacytidine. The dermatological response was accompanied by complete bone marrow remission and trilineage haematological improvement. We suggest that 5‐azacytidine should be considered in the treatment of immune mediated cutaneous manifestations of MDS. |
| doi_str_mv | 10.1111/j.1365-2133.2007.07831.x |
| format | Article |
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We describe a patient in whom a deep neutrophilic dermatosis preceded evolution of disease from refractory anaemia to RAEB (refractory anaemia with excess blasts) and resolved completely on treating the disease with 5‐azacytidine. The dermatological response was accompanied by complete bone marrow remission and trilineage haematological improvement. We suggest that 5‐azacytidine should be considered in the treatment of immune mediated cutaneous manifestations of MDS.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.2007.07831.x</identifier><identifier>PMID: 17408390</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>5‐azacytidine ; Aged ; Anemia, Refractory, with Excess of Blasts - complications ; Antimetabolites, Antineoplastic - therapeutic use ; Azacitidine - therapeutic use ; Biological and medical sciences ; Dermatology ; Head ; Hematologic and hematopoietic diseases ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; myelodysplastic syndromes ; Neck ; neutrophilic dermatosis ; Remission Induction ; Shoulder ; Skin Diseases - drug therapy ; Skin Diseases - etiology</subject><ispartof>British journal of dermatology (1951), 2007-05, Vol.156 (5), p.1039-1041</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4281-182344692200dd525e0b07ebdb5b8e0a4adcbac40bd4e39057abf6260848cad73</citedby><cites>FETCH-LOGICAL-c4281-182344692200dd525e0b07ebdb5b8e0a4adcbac40bd4e39057abf6260848cad73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.2007.07831.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.2007.07831.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18702860$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17408390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raj, K.</creatorcontrib><creatorcontrib>Ho, A.</creatorcontrib><creatorcontrib>Creamer, J.D.</creatorcontrib><creatorcontrib>Du Vivier, A.W.P.</creatorcontrib><creatorcontrib>Salisbury, J.R.</creatorcontrib><creatorcontrib>Mufti, G.J.</creatorcontrib><title>Complete response of deep neutrophilic dermatosis associated with myelodysplastic syndrome to 5‐azacytidine</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary Cutaneous manifestations of myelodysplastic syndromes (MDS) may predict disease progression and a poorer prognosis. We describe a patient in whom a deep neutrophilic dermatosis preceded evolution of disease from refractory anaemia to RAEB (refractory anaemia with excess blasts) and resolved completely on treating the disease with 5‐azacytidine. The dermatological response was accompanied by complete bone marrow remission and trilineage haematological improvement. We suggest that 5‐azacytidine should be considered in the treatment of immune mediated cutaneous manifestations of MDS.</description><subject>5‐azacytidine</subject><subject>Aged</subject><subject>Anemia, Refractory, with Excess of Blasts - complications</subject><subject>Antimetabolites, Antineoplastic - therapeutic use</subject><subject>Azacitidine - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Head</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>myelodysplastic syndromes</subject><subject>Neck</subject><subject>neutrophilic dermatosis</subject><subject>Remission Induction</subject><subject>Shoulder</subject><subject>Skin Diseases - drug therapy</subject><subject>Skin Diseases - etiology</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEuO1DAQhi0EYpqBKyBvYJdQtvNwL1hA89ZIbGBtOXa1xq0kDq60ZjIrjsAZOQkO3WK2eGPL9f1l18cYF1CKvF4dSqGaupBCqVICtCW0Wony9gHb_Cs8ZBvIpQK2jbpgT4gOAEJBDY_ZhWgr0GoLGzbs4jD1OCNPSFMcCXncc4848RGPc4rTdeiDyzdpsHOkQNwSRRfsjJ7fhPmaDwv20S809ZbmjNIy-hQH5HPk9e-fv-yddcscfBjxKXu0tz3hs_N-yb5_eP9t96m4-vrx8-7NVeEqqUUhtFRV1Wxlns37WtYIHbTY-a7uNIKtrHeddRV0vsI8Rt3abt_IBnSlnfWtumQvT32nFH8ckWYzBHLY93bEeCQjc0RulcqgPoEuRaKEezOlMNi0GAFmVW0OZjVqVqNmVW3-qja3Ofr8_MaxG9DfB89uM_DiDFhytt8nO7pA95xuQepm5V6fuJvQ4_LfHzBvv7xbT-oP_S-dMg</recordid><startdate>200705</startdate><enddate>200705</enddate><creator>Raj, K.</creator><creator>Ho, A.</creator><creator>Creamer, J.D.</creator><creator>Du Vivier, A.W.P.</creator><creator>Salisbury, J.R.</creator><creator>Mufti, G.J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>200705</creationdate><title>Complete response of deep neutrophilic dermatosis associated with myelodysplastic syndrome to 5‐azacytidine</title><author>Raj, K. ; Ho, A. ; Creamer, J.D. ; Du Vivier, A.W.P. ; Salisbury, J.R. ; Mufti, G.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4281-182344692200dd525e0b07ebdb5b8e0a4adcbac40bd4e39057abf6260848cad73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>5‐azacytidine</topic><topic>Aged</topic><topic>Anemia, Refractory, with Excess of Blasts - complications</topic><topic>Antimetabolites, Antineoplastic - therapeutic use</topic><topic>Azacitidine - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Head</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>myelodysplastic syndromes</topic><topic>Neck</topic><topic>neutrophilic dermatosis</topic><topic>Remission Induction</topic><topic>Shoulder</topic><topic>Skin Diseases - drug therapy</topic><topic>Skin Diseases - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raj, K.</creatorcontrib><creatorcontrib>Ho, A.</creatorcontrib><creatorcontrib>Creamer, J.D.</creatorcontrib><creatorcontrib>Du Vivier, A.W.P.</creatorcontrib><creatorcontrib>Salisbury, J.R.</creatorcontrib><creatorcontrib>Mufti, G.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raj, K.</au><au>Ho, A.</au><au>Creamer, J.D.</au><au>Du Vivier, A.W.P.</au><au>Salisbury, J.R.</au><au>Mufti, G.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complete response of deep neutrophilic dermatosis associated with myelodysplastic syndrome to 5‐azacytidine</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2007-05</date><risdate>2007</risdate><volume>156</volume><issue>5</issue><spage>1039</spage><epage>1041</epage><pages>1039-1041</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary Cutaneous manifestations of myelodysplastic syndromes (MDS) may predict disease progression and a poorer prognosis. We describe a patient in whom a deep neutrophilic dermatosis preceded evolution of disease from refractory anaemia to RAEB (refractory anaemia with excess blasts) and resolved completely on treating the disease with 5‐azacytidine. The dermatological response was accompanied by complete bone marrow remission and trilineage haematological improvement. We suggest that 5‐azacytidine should be considered in the treatment of immune mediated cutaneous manifestations of MDS.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17408390</pmid><doi>10.1111/j.1365-2133.2007.07831.x</doi><tpages>3</tpages></addata></record> |
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| ispartof | British journal of dermatology (1951), 2007-05, Vol.156 (5), p.1039-1041 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Wiley Online Library All Journals |
| subjects | 5‐azacytidine Aged Anemia, Refractory, with Excess of Blasts - complications Antimetabolites, Antineoplastic - therapeutic use Azacitidine - therapeutic use Biological and medical sciences Dermatology Head Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences myelodysplastic syndromes Neck neutrophilic dermatosis Remission Induction Shoulder Skin Diseases - drug therapy Skin Diseases - etiology |
| title | Complete response of deep neutrophilic dermatosis associated with myelodysplastic syndrome to 5‐azacytidine |
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