Complete response of deep neutrophilic dermatosis associated with myelodysplastic syndrome to 5‐azacytidine

Summary Cutaneous manifestations of myelodysplastic syndromes (MDS) may predict disease progression and a poorer prognosis. We describe a patient in whom a deep neutrophilic dermatosis preceded evolution of disease from refractory anaemia to RAEB (refractory anaemia with excess blasts) and resolved completely on treating the disease with 5‐azacytidine. The dermatological response was accompanied by complete bone marrow remission and trilineage haematological improvement. We suggest that 5‐azacytidine should be considered in the treatment of immune mediated cutaneous manifestations of MDS.