Determination of serum zinc-alpha-2-glycoprotein in patients with metabolic syndrome by a new ELISA

To develop an assay for the determination of ZAG in human serum, and to investigate its clinical relevance as a marker of metabolic syndrome. A new sandwich ELISA was introduced and clinically tested. ZAG serum level did not differentiate healthy subjects (27.4 ± 8.3 mg/L; N = 132) from patients wit...

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Veröffentlicht in:	Clinical biochemistry 2008-03, Vol.41 (4), p.313-316
Hauptverfasser:	Stejskal, D., Karpíšek, M., Reutová, H., Stejskal, P., Kotolová, H., Kollár, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Blood Glucose - metabolism Creatinine - blood ELISA Enzyme-Linked Immunosorbent Assay - methods Female Humans Male Metabolic syndrome Metabolic Syndrome - blood Middle Aged Obesity Seminal Plasma Proteins - blood Uric Acid - blood Zinc-alpha-2-glycoprotein
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Beschreibung
Zusammenfassung:	To develop an assay for the determination of ZAG in human serum, and to investigate its clinical relevance as a marker of metabolic syndrome. A new sandwich ELISA was introduced and clinically tested. ZAG serum level did not differentiate healthy subjects (27.4 ± 8.3 mg/L; N = 132) from patients with metabolic syndrome (24.9 ± 8.1; N = 92). ZAG correlated with glucose, creatinine and uric acid. The immunoassay offers a new research tool for glucose metabolism.
ISSN:	0009-9120 1873-2933
DOI:	10.1016/j.clinbiochem.2007.11.010