Intrathecal administration of antioxidants attenuates mechanical pain hypersensitivity induced by REM sleep deprivation in the rat

Intrathecal administration of antioxidants attenuates mechanical pain hypersensitivity induced by REM sleep deprivation in the rat

Research highlights ► Mechanical pain hypersensitivity was increased in the sleep-deprived rat. ► Intrathecally administered antioxidants reduced hypersensitivity in sleep-deprived animals. ► Spinal oxidative stress contributes to pain hypersensitivity induced by sleep deprivation.

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Veröffentlicht in:Scandinavian journal of pain 2011-04, Vol.2 (2), p.64-69
Hauptverfasser: Wei, Hong, Huang, Jin-Lu, Hao, Bin, Wang, Yan-Chao, Nian, Gong, Ma, Ai-Niu, Li, Xin-Yan, Wang, Yong-Xiang, Pertovaara, Antti
Format: Artikel
Sprache:eng
Schlagworte:
Antioxidant
Internal Medicine
Oxidative stress
Pain hypersensitivity
Pain Medicine
REM sleep deprivation
Spinal sensitization
Tactile allodynia
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Zusammenfassung:Research highlights ► Mechanical pain hypersensitivity was increased in the sleep-deprived rat. ► Intrathecally administered antioxidants reduced hypersensitivity in sleep-deprived animals. ► Spinal oxidative stress contributes to pain hypersensitivity induced by sleep deprivation.
ISSN:1877-8860
1877-8879
DOI:10.1016/j.sjpain.2011.01.001