Insect Growth Regulatory Effects of Linear Diterpenoids and Derivatives from Baccharis thymifolia

Linear diterpenes isolated from aerial parts of Baccharis thymifolia (1–3) were tested for insect growth inhibitory activity against Tenebrio molitor larvae. Compounds 4–16 were prepared by various chemical transformations. The diterpenes 6,10-(E,E)-thymifodioic acid (1), the butenolide 3, and the d...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2008-02, Vol.71 (2), p.190-194
Hauptverfasser:	Juan Hikawczuk, Virginia E, Saad, J. Roberto, Giordano, Oscar S, García, Celina, Martín, Tomás, Martín, Víctor S, Sosa, Marta E, Tonn, Carlos E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Argentina Baccharis Baccharis - chemistry Baccharis thymifolia Biological and medical sciences butenolide chemical structure Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology diterpenoids General pharmacology insect growth regulators Insecticides - chemistry Insecticides - isolation & purification Insecticides - pharmacology Larva - drug effects Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry spectral analysis Tenebrio - drug effects Tenebrio molitor thymifodioic acid
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Beschreibung
Zusammenfassung:	Linear diterpenes isolated from aerial parts of Baccharis thymifolia (1–3) were tested for insect growth inhibitory activity against Tenebrio molitor larvae. Compounds 4–16 were prepared by various chemical transformations. The diterpenes 6,10-(E,E)-thymifodioic acid (1), the butenolide 3, and the derivatives 4, 11, and 14 produced developmental deficiencies in assays using topical application on fifth instar larvae of T. molitor. Compound 3 is a new natural product.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np070392o