Pregnancy outcomes from more than 1,800 in vitro fertilization cycles with the use of 24-chromosome single-nucleotide polymorphism–based preimplantation genetic testing for aneuploidy

To measure in vitro fertilization (IVF) outcomes following 24-chromosome single‒nucleotide-polymorphism (SNP)–based preimplantation genetic testing for aneuploidy (PGT-A) and euploid embryo transfer. Retrospective. Fertility clinics and laboratory. Women 20–46 years of age undergoing IVF treatment. Twenty-four-chromosome SNP-based PGT-A of day 5/6 embryo biopsies. Maternal age–stratified implantation, clinical pregnancy, and live birth rates per embryo transfer; miscarriage rates; and number of embryo transfers per patient needed to achieve a live birth. An implantation rate of 69.9%, clinical pregnancy rate per transfer of 70.6%, and live birth rate per transfer of 64.5% were observed in 1,621 nondonor frozen cycles with the use of SNP-based PGT-A. In addition, SNP-based PGT-A outcomes, when measured per cycle with transfer, remained relatively constant across all maternal ages; when measured per cycle initiated, they decreased as maternal age increased. Miscarriage rates were ∼5% in women ≤40 years old. No statistically significant differences in pregnancy outcomes were found for single-embryo transfers (SET) versus double-embryo transfers with SNP-based PGT-A. On average, 1.38 embryo transfers per patient were needed to achieve a live birth in nondonor cycles. Our findings that SNP-based PGT-A can mitigate the negative effects of maternal age on IVF outcomes in cycles with transfer, and that pregnancy outcomes from SET cycles are not significantly different from those of double-embryo transfer cycles, support the use of SET when transfers are combined with SNP-based PGT-A. Resultados de embarazos de más de 1800 ciclos de fecundación in vitro mediante polimorfismosde nucleótido único en 24 cromosomas basado en el diagnóstico genético preimplantacional para aneuploidías Medir los resultados de fecundación in vitro (FIV) con el uso de polimorfismos de nucleótido único en 24 cromosomas (SNP) basado en el estudio genético preimplantacional para aneuploidías (PGT-A) y transferencia de embriones euploides. Retrospectivo. Clínicas y Laboratorios de Fertilidad. Mujeres de 20 a 46 años de edad sometidas a tratamientos de FIV. Polimorfismo de nucleótido único de 24 cromosomas basado en el estudio genético preimplantacional para aneuploidías de biopsias de embriones de día 5/6. Implantación estratificada por edad materna, embarazo clínico y tasa de recién nacido vivo por embrión transferido; tasas de pérdida/aborto y número de transferencias embrionarias por pacien