Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy

Concerns have been raised about the risk of severe dengue in children who were seronegative before receipt of a recently deployed dengue vaccine. In this study, data from field trials were analyzed to assess the effect of baseline serostatus on subsequent severe illness.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2018-07, Vol.379 (4), p.327-340
Hauptverfasser:	Sridhar, Saranya, Luedtke, Alexander, Langevin, Edith, Zhu, Ming, Bonaparte, Matthew, Machabert, Tifany, Savarino, Stephen, Zambrano, Betzana, Moureau, Annick, Khromava, Alena, Moodie, Zoe, Westling, Ted, Mascareñas, Cesar, Frago, Carina, Cortés, Margarita, Chansinghakul, Danaya, Noriega, Fernando, Bouckenooghe, Alain, Chen, Josh, Ng, Su-Peing, Gilbert, Peter B, Gurunathan, Sanjay, DiazGranados, Carlos A
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age groups Dengue fever Enzyme-linked immunosorbent assay Hospitalization Immunization Immunoglobulin G Infections Methods Tropical diseases Vaccination Vaccines
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Beschreibung
Zusammenfassung:	Concerns have been raised about the risk of severe dengue in children who were seronegative before receipt of a recently deployed dengue vaccine. In this study, data from field trials were analyzed to assess the effect of baseline serostatus on subsequent severe illness.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1800820