Risk of diabetes in HIV‐infected patients is associated with cirrhosis but not with chronic HCV coinfection in a French nationwide HIV cohort

Summary Background Both human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections have been reportedly associated with a higher risk of diabetes mellitus (DM) but results are conflicting. Aims To determine whether there is an association between chronic HCV and the incidence of DM, and to study the role of factors such as cirrhosis, IFN‐based HCV therapy, sustained virologic response (SVR) and chronic HBV infection among patients living with HIV (PLHIV) followed in a large French multicentre cohort in the combination antiretroviral therapy (cART) era. Methods All PLHIV followed up in the Dat’AIDS cohort were eligible. Cox models for survival analysis were used to study the time to occurrence of DM. Results Among 28 699 PLHIV, 4004 patients had chronic HCV infection. The mean duration of HCV follow‐up was 12.5 ± 8.1 years. The rate ratio of DM was 2.74 per 1000 person‐years. By multivariate analysis, increasing age, body mass index>25, AIDS status, nadir CD4 cell count ≤200/mm3, detectable HIV viral load and cirrhosis (HR 2.26 95% CI 1.14‐1.18; P