Antineoplastic Agents. 558. Ampelocissus sp. Cancer Cell Growth Inhibitory Constituentsh

Antineoplastic Agents. 558. Ampelocissus sp. Cancer Cell Growth Inhibitory Constituentsh

An investigation of the Phillippine Ampelocissus sp. roots for cancer cell growth inhibitory components led to the isolation of a new acetogenin characterized as 22-epicalamistrin (1) employing primarily 2D NMR and high- resolution mass spectral analysis. Two other antineoplastic constituents proved...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2008-01, Vol.71 (1), p.130-133
Hauptverfasser: Pettit, George R, Mukku, Venugopal JRV, Cragg, Gordon, Herald, Delbert L, Knight, John C, Herald, Cherry L, Chapuis, Jean-Charles
Format: Artikel
Sprache:eng
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Zusammenfassung:An investigation of the Phillippine Ampelocissus sp. roots for cancer cell growth inhibitory components led to the isolation of a new acetogenin characterized as 22-epicalamistrin (1) employing primarily 2D NMR and high- resolution mass spectral analysis. Two other antineoplastic constituents proved to be the known acetogenin uvaribonin (2) and chalcone 3. Constituents 1-3 were all found to show significant cancer cell growth inhibitory activity against a panel of human cancer cell lines.
ISSN:0163-3864
1520-6025
DOI:10.1021/np068050q