Prevalence and risk factors of antibodies to human leukocyte antigens in haploidentical stem cell transplantation candidates: A multi-center study
We investigated the prevalence of and risk factors for antibodies to HLA in 1663 haploidentical transplant candidates. Among these cases, 349 (21.0%) showed positive panel-reactive antibody (PRA) either for class I or class II HLA. Multivariate analysis showed the following: i) risk factors associat...
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| Veröffentlicht in: | Human immunology 2018-09, Vol.79 (9), p.672-677 |
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| creator | Huo, Ming-Rui Xu, Ya-Jing Zhai, Shu-Zhen Lv, Meng Wang, Yu Cao, Le-Qing Xu, Lan-Ping Zhang, Xiao-Hui Chen, Huan Chen, Yu-Hong Wang, Feng-Rong Han, Wei Sun, Yu-Qian Yan, Chen-Hua Tang, Fei-Fei Mo, Xiao-Dong Zhao, Ming-Feng Liu, Kai-Yan Huang, Xiao-Jun Chang, Ying-Jun |
| description | We investigated the prevalence of and risk factors for antibodies to HLA in 1663 haploidentical transplant candidates. Among these cases, 349 (21.0%) showed positive panel-reactive antibody (PRA) either for class I or class II HLA. Multivariate analysis showed the following: i) risk factors associated with the prevalence of PRA either for class I or class II HLA were female gender (P = 0.018), prior transfusions (P |
| doi_str_mv | 10.1016/j.humimm.2018.06.003 |
| format | Article |
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Among these cases, 349 (21.0%) showed positive panel-reactive antibody (PRA) either for class I or class II HLA. Multivariate analysis showed the following: i) risk factors associated with the prevalence of PRA either for class I or class II HLA were female gender (P = 0.018), prior transfusions (P < 0.001) or pregnancy (P < 0.001), and cases with MDS (P = 0.018); compared to other patients, subjects with ALL had a lower prevalence of class I antibodies (P = 0.017); and ii) risk factors associated with the prevalence of PRA both for class I and class II HLA were female gender (P = 0.014), prior transfusions (P = 0.003), previous pregnancy (P < 0.001), and diagnosis with MDS (P = 0.035). The percentages of antibodies against different antigens coded by the different HLA loci, including HLA-A, -B, -C, -DP, -DQ, and -DR, among all cases were 15.6%, 17.3%, 10.5%, 5.6%, 8.5%, and 9.7%, respectively. Risk factors associated with specific antibodies against HLA-A, -B, -C, -DP, -DQ, and -DR were female gender, prior transfusion, previous pregnancy, and underlying disease. Our findings suggest that gender, prior pregnancy, transfusion and underlying diseases are risk factors for HLA sensitization, which could guide HLA antibody monitor and donor selection.</description><identifier>ISSN: 0198-8859</identifier><identifier>EISSN: 1879-1166</identifier><identifier>DOI: 10.1016/j.humimm.2018.06.003</identifier><identifier>PMID: 29890181</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Anti-HLA antibody ; Child ; Child, Preschool ; China - epidemiology ; Female ; HLA Antigens - genetics ; Humans ; Infant ; Isoantibodies - biosynthesis ; Luminex ; Male ; Middle Aged ; Prevalence ; Risk Factors ; Sensitizing events ; Stem Cell Transplantation ; Stem cells transplantation ; Transplant Recipients ; Transplantation, Haploidentical ; Waiting Lists ; Young Adult</subject><ispartof>Human immunology, 2018-09, Vol.79 (9), p.672-677</ispartof><rights>2018 The Authors</rights><rights>Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-2210f2cdddd1f8cc08eabe1763065bf9cbe66ff9d4137a2401e400ec191dc6153</citedby><cites>FETCH-LOGICAL-c408t-2210f2cdddd1f8cc08eabe1763065bf9cbe66ff9d4137a2401e400ec191dc6153</cites><orcidid>0000-0002-6124-6050</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.humimm.2018.06.003$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29890181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huo, Ming-Rui</creatorcontrib><creatorcontrib>Xu, Ya-Jing</creatorcontrib><creatorcontrib>Zhai, Shu-Zhen</creatorcontrib><creatorcontrib>Lv, Meng</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Cao, Le-Qing</creatorcontrib><creatorcontrib>Xu, Lan-Ping</creatorcontrib><creatorcontrib>Zhang, Xiao-Hui</creatorcontrib><creatorcontrib>Chen, Huan</creatorcontrib><creatorcontrib>Chen, Yu-Hong</creatorcontrib><creatorcontrib>Wang, Feng-Rong</creatorcontrib><creatorcontrib>Han, Wei</creatorcontrib><creatorcontrib>Sun, Yu-Qian</creatorcontrib><creatorcontrib>Yan, Chen-Hua</creatorcontrib><creatorcontrib>Tang, Fei-Fei</creatorcontrib><creatorcontrib>Mo, Xiao-Dong</creatorcontrib><creatorcontrib>Zhao, Ming-Feng</creatorcontrib><creatorcontrib>Liu, Kai-Yan</creatorcontrib><creatorcontrib>Huang, Xiao-Jun</creatorcontrib><creatorcontrib>Chang, Ying-Jun</creatorcontrib><title>Prevalence and risk factors of antibodies to human leukocyte antigens in haploidentical stem cell transplantation candidates: A multi-center study</title><title>Human immunology</title><addtitle>Hum Immunol</addtitle><description>We investigated the prevalence of and risk factors for antibodies to HLA in 1663 haploidentical transplant candidates. Among these cases, 349 (21.0%) showed positive panel-reactive antibody (PRA) either for class I or class II HLA. Multivariate analysis showed the following: i) risk factors associated with the prevalence of PRA either for class I or class II HLA were female gender (P = 0.018), prior transfusions (P < 0.001) or pregnancy (P < 0.001), and cases with MDS (P = 0.018); compared to other patients, subjects with ALL had a lower prevalence of class I antibodies (P = 0.017); and ii) risk factors associated with the prevalence of PRA both for class I and class II HLA were female gender (P = 0.014), prior transfusions (P = 0.003), previous pregnancy (P < 0.001), and diagnosis with MDS (P = 0.035). The percentages of antibodies against different antigens coded by the different HLA loci, including HLA-A, -B, -C, -DP, -DQ, and -DR, among all cases were 15.6%, 17.3%, 10.5%, 5.6%, 8.5%, and 9.7%, respectively. Risk factors associated with specific antibodies against HLA-A, -B, -C, -DP, -DQ, and -DR were female gender, prior transfusion, previous pregnancy, and underlying disease. Our findings suggest that gender, prior pregnancy, transfusion and underlying diseases are risk factors for HLA sensitization, which could guide HLA antibody monitor and donor selection.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-HLA antibody</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>China - epidemiology</subject><subject>Female</subject><subject>HLA Antigens - genetics</subject><subject>Humans</subject><subject>Infant</subject><subject>Isoantibodies - biosynthesis</subject><subject>Luminex</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Sensitizing events</subject><subject>Stem Cell Transplantation</subject><subject>Stem cells transplantation</subject><subject>Transplant Recipients</subject><subject>Transplantation, Haploidentical</subject><subject>Waiting Lists</subject><subject>Young Adult</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxi1ERZfCGyDkI5eEcZJ1bA5IVcU_qVI5tGfLscfUWydebKfSvgZPjJctHPFlpPH3-RvPj5A3DFoGjL_ftffr7Oe57YCJFngL0D8jGyZG2TDG-XOyASZFI8RWnpOXOe8AYIRxeEHOOylkdbEN-fU94aMOuBikerE0-fxAnTYlpkyjq73ip2g9ZloirYl6oQHXh2gOBf_c_sAlU7_Qe70P0VusLaMDzQVnajAEWpJe8j5UrS4-LtTUHG91wfyBXtJ5DcU3ptowVdNqD6_ImdMh4-unekHuPn-6vfraXN98-XZ1ed2YAURpuo6B64ythzlhDAjUE7KR98C3k5NmQs6dk3Zg_ai7ARgOAGiYZNZwtu0vyLvTu_sUf66Yi5p9Pk6sF4xrVh1sB9mPgosqHU5Sk2LOCZ3aJz_rdFAM1JGG2qkTDXWkoYCrSqPa3j4lrNOM9p_p7_qr4ONJgPWfjx6TysYfWVif0BRlo_9_wm8ph6F6</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Huo, Ming-Rui</creator><creator>Xu, Ya-Jing</creator><creator>Zhai, Shu-Zhen</creator><creator>Lv, Meng</creator><creator>Wang, Yu</creator><creator>Cao, Le-Qing</creator><creator>Xu, Lan-Ping</creator><creator>Zhang, Xiao-Hui</creator><creator>Chen, Huan</creator><creator>Chen, Yu-Hong</creator><creator>Wang, Feng-Rong</creator><creator>Han, Wei</creator><creator>Sun, Yu-Qian</creator><creator>Yan, Chen-Hua</creator><creator>Tang, Fei-Fei</creator><creator>Mo, Xiao-Dong</creator><creator>Zhao, Ming-Feng</creator><creator>Liu, Kai-Yan</creator><creator>Huang, Xiao-Jun</creator><creator>Chang, Ying-Jun</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6124-6050</orcidid></search><sort><creationdate>201809</creationdate><title>Prevalence and risk factors of antibodies to human leukocyte antigens in haploidentical stem cell transplantation candidates: A multi-center study</title><author>Huo, Ming-Rui ; Xu, Ya-Jing ; Zhai, Shu-Zhen ; Lv, Meng ; Wang, Yu ; Cao, Le-Qing ; Xu, Lan-Ping ; Zhang, Xiao-Hui ; Chen, Huan ; Chen, Yu-Hong ; Wang, Feng-Rong ; Han, Wei ; Sun, Yu-Qian ; Yan, Chen-Hua ; Tang, Fei-Fei ; Mo, Xiao-Dong ; Zhao, Ming-Feng ; Liu, Kai-Yan ; Huang, Xiao-Jun ; Chang, Ying-Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-2210f2cdddd1f8cc08eabe1763065bf9cbe66ff9d4137a2401e400ec191dc6153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anti-HLA antibody</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>China - epidemiology</topic><topic>Female</topic><topic>HLA Antigens - genetics</topic><topic>Humans</topic><topic>Infant</topic><topic>Isoantibodies - biosynthesis</topic><topic>Luminex</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Sensitizing events</topic><topic>Stem Cell Transplantation</topic><topic>Stem cells transplantation</topic><topic>Transplant Recipients</topic><topic>Transplantation, Haploidentical</topic><topic>Waiting Lists</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huo, Ming-Rui</creatorcontrib><creatorcontrib>Xu, Ya-Jing</creatorcontrib><creatorcontrib>Zhai, Shu-Zhen</creatorcontrib><creatorcontrib>Lv, Meng</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Cao, Le-Qing</creatorcontrib><creatorcontrib>Xu, Lan-Ping</creatorcontrib><creatorcontrib>Zhang, Xiao-Hui</creatorcontrib><creatorcontrib>Chen, Huan</creatorcontrib><creatorcontrib>Chen, Yu-Hong</creatorcontrib><creatorcontrib>Wang, Feng-Rong</creatorcontrib><creatorcontrib>Han, Wei</creatorcontrib><creatorcontrib>Sun, Yu-Qian</creatorcontrib><creatorcontrib>Yan, Chen-Hua</creatorcontrib><creatorcontrib>Tang, Fei-Fei</creatorcontrib><creatorcontrib>Mo, Xiao-Dong</creatorcontrib><creatorcontrib>Zhao, Ming-Feng</creatorcontrib><creatorcontrib>Liu, Kai-Yan</creatorcontrib><creatorcontrib>Huang, Xiao-Jun</creatorcontrib><creatorcontrib>Chang, Ying-Jun</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huo, Ming-Rui</au><au>Xu, Ya-Jing</au><au>Zhai, Shu-Zhen</au><au>Lv, Meng</au><au>Wang, Yu</au><au>Cao, Le-Qing</au><au>Xu, Lan-Ping</au><au>Zhang, Xiao-Hui</au><au>Chen, Huan</au><au>Chen, Yu-Hong</au><au>Wang, Feng-Rong</au><au>Han, Wei</au><au>Sun, Yu-Qian</au><au>Yan, Chen-Hua</au><au>Tang, Fei-Fei</au><au>Mo, Xiao-Dong</au><au>Zhao, Ming-Feng</au><au>Liu, Kai-Yan</au><au>Huang, Xiao-Jun</au><au>Chang, Ying-Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and risk factors of antibodies to human leukocyte antigens in haploidentical stem cell transplantation candidates: A multi-center study</atitle><jtitle>Human immunology</jtitle><addtitle>Hum Immunol</addtitle><date>2018-09</date><risdate>2018</risdate><volume>79</volume><issue>9</issue><spage>672</spage><epage>677</epage><pages>672-677</pages><issn>0198-8859</issn><eissn>1879-1166</eissn><abstract>We investigated the prevalence of and risk factors for antibodies to HLA in 1663 haploidentical transplant candidates. Among these cases, 349 (21.0%) showed positive panel-reactive antibody (PRA) either for class I or class II HLA. Multivariate analysis showed the following: i) risk factors associated with the prevalence of PRA either for class I or class II HLA were female gender (P = 0.018), prior transfusions (P < 0.001) or pregnancy (P < 0.001), and cases with MDS (P = 0.018); compared to other patients, subjects with ALL had a lower prevalence of class I antibodies (P = 0.017); and ii) risk factors associated with the prevalence of PRA both for class I and class II HLA were female gender (P = 0.014), prior transfusions (P = 0.003), previous pregnancy (P < 0.001), and diagnosis with MDS (P = 0.035). The percentages of antibodies against different antigens coded by the different HLA loci, including HLA-A, -B, -C, -DP, -DQ, and -DR, among all cases were 15.6%, 17.3%, 10.5%, 5.6%, 8.5%, and 9.7%, respectively. Risk factors associated with specific antibodies against HLA-A, -B, -C, -DP, -DQ, and -DR were female gender, prior transfusion, previous pregnancy, and underlying disease. Our findings suggest that gender, prior pregnancy, transfusion and underlying diseases are risk factors for HLA sensitization, which could guide HLA antibody monitor and donor selection.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29890181</pmid><doi>10.1016/j.humimm.2018.06.003</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6124-6050</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Anti-HLA antibody Child Child, Preschool China - epidemiology Female HLA Antigens - genetics Humans Infant Isoantibodies - biosynthesis Luminex Male Middle Aged Prevalence Risk Factors Sensitizing events Stem Cell Transplantation Stem cells transplantation Transplant Recipients Transplantation, Haploidentical Waiting Lists Young Adult |
| title | Prevalence and risk factors of antibodies to human leukocyte antigens in haploidentical stem cell transplantation candidates: A multi-center study |
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