Prevalence and risk factors of antibodies to human leukocyte antigens in haploidentical stem cell transplantation candidates: A multi-center study

We investigated the prevalence of and risk factors for antibodies to HLA in 1663 haploidentical transplant candidates. Among these cases, 349 (21.0%) showed positive panel-reactive antibody (PRA) either for class I or class II HLA. Multivariate analysis showed the following: i) risk factors associat...

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Veröffentlicht in:	Human immunology 2018-09, Vol.79 (9), p.672-677
Hauptverfasser:	Huo, Ming-Rui, Xu, Ya-Jing, Zhai, Shu-Zhen, Lv, Meng, Wang, Yu, Cao, Le-Qing, Xu, Lan-Ping, Zhang, Xiao-Hui, Chen, Huan, Chen, Yu-Hong, Wang, Feng-Rong, Han, Wei, Sun, Yu-Qian, Yan, Chen-Hua, Tang, Fei-Fei, Mo, Xiao-Dong, Zhao, Ming-Feng, Liu, Kai-Yan, Huang, Xiao-Jun, Chang, Ying-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anti-HLA antibody Child Child, Preschool China - epidemiology Female HLA Antigens - genetics Humans Infant Isoantibodies - biosynthesis Luminex Male Middle Aged Prevalence Risk Factors Sensitizing events Stem Cell Transplantation Stem cells transplantation Transplant Recipients Transplantation, Haploidentical Waiting Lists Young Adult
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Zusammenfassung:	We investigated the prevalence of and risk factors for antibodies to HLA in 1663 haploidentical transplant candidates. Among these cases, 349 (21.0%) showed positive panel-reactive antibody (PRA) either for class I or class II HLA. Multivariate analysis showed the following: i) risk factors associated with the prevalence of PRA either for class I or class II HLA were female gender (P = 0.018), prior transfusions (P
ISSN:	0198-8859 1879-1166
DOI:	10.1016/j.humimm.2018.06.003