Concordant up-regulation of cytochrome P450 Cyp3a11, testosterone oxidation and androgen receptor expression in mouse brain after xenobiotic treatment

Inactivation of testosterone by specific hydroxylations is a main function of cytochrome P450 (P450, CYP) in the brain. Recent data imply that induction of brain P450s by neuroactive drugs alters steroid hormone levels and endocrine signalling, giving rise to endocrine disorders. In this study, we i...

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Veröffentlicht in:Journal of neurochemistry 2009-04, Vol.109 (2), p.670-681
Hauptverfasser: Meyer, Ralf Peter, Gehlhaus, Marcel, Schwab, Ricarda, Bürck, Carolin, Knoth, Rolf, Hagemeyer, Christoph Eugen
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Sprache:eng
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