Yeast adaptation to mancozeb involves the up-regulation of FLR1 under the coordinate control of Yap1, Rpn4, Pdr3, and Yrr1

FLR1 gene, encoding a multidrug resistance (MDR) transporter of the major facilitator superfamily (MFS) was found to confer resistance to the fungicide mancozeb in Saccharomyces cerevisiae. This agrochemical has been linked to the development of Parkinson disease and cancer. Yeast response to mancoz...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-03, Vol.367 (2), p.249-255
Hauptverfasser:	Teixeira, Miguel Cacho, Dias, Paulo Jorge, Simões, Tânia, Sá-Correia, Isabel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Drug Resistance, Fungal - physiology FLR1 Fungicides, Industrial - administration & dosage Gene Expression Regulation, Fungal - drug effects Gene Expression Regulation, Fungal - physiology Mancozeb Maneb - administration & dosage Membrane Transport Proteins - metabolism MFS–MDR transporters Multidrug resistance Organic Anion Transporters Pdr1/Pdr3 Rpn4 Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - physiology Saccharomyces cerevisiae Proteins - metabolism Transcription Factors - metabolism Transcriptional regulatory network Up-Regulation - drug effects Yap1 Yrr1 Zineb - administration & dosage
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