Celastrol as a pentacyclic triterpenoid with chemopreventive properties

Celastrol is a highly investigated anticancer moiety. It is a pentacyclic triterpenoid, isolated several decades ago with promising role in chemoprevention. Celastrol has been found to target multiple proinflammatory, angiogenic and metastatic proteins. Inhibition of these targets results in signifi...

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Veröffentlicht in:	Pharmaceutical patent analyst 2018-07, Vol.7 (4), p.155-167
Hauptverfasser:	Yadav, Priya, Jaswal, Vishal, Sharma, Ajay, Kashyap, Dharambir, Tuli, Hardeep S, Garg, Vivek K, Das, Shonkor K, Srinivas
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals anti-inflammation antiangiogenesis anticancer Antifungal agents antimetastasis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use antioxidant Antioxidants Apoptosis Cancer celastrol Cell adhesion & migration Disease Humans Kinases Medical prognosis Melanoma Metastasis Natural products Neoplasms - drug therapy Patents as Topic Prostate Triterpenes - chemistry Triterpenes - pharmacology Triterpenes - therapeutic use
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