Celastrol as a pentacyclic triterpenoid with chemopreventive properties

Celastrol is a highly investigated anticancer moiety. It is a pentacyclic triterpenoid, isolated several decades ago with promising role in chemoprevention. Celastrol has been found to target multiple proinflammatory, angiogenic and metastatic proteins. Inhibition of these targets results in signifi...

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Veröffentlicht in:	Pharmaceutical patent analyst 2018-07, Vol.7 (4), p.155-167
Hauptverfasser:	Yadav, Priya, Jaswal, Vishal, Sharma, Ajay, Kashyap, Dharambir, Tuli, Hardeep S, Garg, Vivek K, Das, Shonkor K, Srinivas
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals anti-inflammation antiangiogenesis anticancer Antifungal agents antimetastasis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use antioxidant Antioxidants Apoptosis Cancer celastrol Cell adhesion & migration Disease Humans Kinases Medical prognosis Melanoma Metastasis Natural products Neoplasms - drug therapy Patents as Topic Prostate Triterpenes - chemistry Triterpenes - pharmacology Triterpenes - therapeutic use
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Beschreibung
Zusammenfassung:	Celastrol is a highly investigated anticancer moiety. It is a pentacyclic triterpenoid, isolated several decades ago with promising role in chemoprevention. Celastrol has been found to target multiple proinflammatory, angiogenic and metastatic proteins. Inhibition of these targets results in significant reduction of cancer growth, survival and metastasis. This review summarizes the varied molecular targets of celastrol along with insight into the various recently published clinical, preclinical and industrial patents (2011-2017).
ISSN:	2046-8954 2046-8962
DOI:	10.4155/ppa-2017-0035