Celastrol as a pentacyclic triterpenoid with chemopreventive properties
Celastrol is a highly investigated anticancer moiety. It is a pentacyclic triterpenoid, isolated several decades ago with promising role in chemoprevention. Celastrol has been found to target multiple proinflammatory, angiogenic and metastatic proteins. Inhibition of these targets results in signifi...
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| Veröffentlicht in: | Pharmaceutical patent analyst 2018-07, Vol.7 (4), p.155-167 |
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| container_title | Pharmaceutical patent analyst |
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| creator | Yadav, Priya Jaswal, Vishal Sharma, Ajay Kashyap, Dharambir Tuli, Hardeep S Garg, Vivek K Das, Shonkor K Srinivas |
| description | Celastrol is a highly investigated anticancer moiety. It is a pentacyclic triterpenoid, isolated several decades ago with promising role in chemoprevention. Celastrol has been found to target multiple proinflammatory, angiogenic and metastatic proteins. Inhibition of these targets results in significant reduction of cancer growth, survival and metastasis. This review summarizes the varied molecular targets of celastrol along with insight into the various recently published clinical, preclinical and industrial patents (2011-2017). |
| doi_str_mv | 10.4155/ppa-2017-0035 |
| format | Article |
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It is a pentacyclic triterpenoid, isolated several decades ago with promising role in chemoprevention. Celastrol has been found to target multiple proinflammatory, angiogenic and metastatic proteins. Inhibition of these targets results in significant reduction of cancer growth, survival and metastasis. This review summarizes the varied molecular targets of celastrol along with insight into the various recently published clinical, preclinical and industrial patents (2011-2017).</description><identifier>ISSN: 2046-8954</identifier><identifier>EISSN: 2046-8962</identifier><identifier>DOI: 10.4155/ppa-2017-0035</identifier><identifier>PMID: 29882724</identifier><language>eng</language><publisher>England: Future Science Ltd</publisher><subject>Angiogenesis ; Animals ; anti-inflammation ; antiangiogenesis ; anticancer ; Antifungal agents ; antimetastasis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; antioxidant ; Antioxidants ; Apoptosis ; Cancer ; celastrol ; Cell adhesion & migration ; Disease ; Humans ; Kinases ; Medical prognosis ; Melanoma ; Metastasis ; Natural products ; Neoplasms - drug therapy ; Patents as Topic ; Prostate ; Triterpenes - chemistry ; Triterpenes - pharmacology ; Triterpenes - therapeutic use</subject><ispartof>Pharmaceutical patent analyst, 2018-07, Vol.7 (4), p.155-167</ispartof><rights>2018 Newlands Press</rights><rights>Copyright Newlands Press Jul 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-d978811201b841c82ef42759a24b9fdf1981eee4b9b022fc51e350873024430d3</citedby><cites>FETCH-LOGICAL-c371t-d978811201b841c82ef42759a24b9fdf1981eee4b9b022fc51e350873024430d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29882724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yadav, Priya</creatorcontrib><creatorcontrib>Jaswal, Vishal</creatorcontrib><creatorcontrib>Sharma, Ajay</creatorcontrib><creatorcontrib>Kashyap, Dharambir</creatorcontrib><creatorcontrib>Tuli, Hardeep S</creatorcontrib><creatorcontrib>Garg, Vivek K</creatorcontrib><creatorcontrib>Das, Shonkor K</creatorcontrib><creatorcontrib>Srinivas</creatorcontrib><title>Celastrol as a pentacyclic triterpenoid with chemopreventive properties</title><title>Pharmaceutical patent analyst</title><addtitle>Pharm Pat Anal</addtitle><description>Celastrol is a highly investigated anticancer moiety. 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| subjects | Angiogenesis Animals anti-inflammation antiangiogenesis anticancer Antifungal agents antimetastasis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use antioxidant Antioxidants Apoptosis Cancer celastrol Cell adhesion & migration Disease Humans Kinases Medical prognosis Melanoma Metastasis Natural products Neoplasms - drug therapy Patents as Topic Prostate Triterpenes - chemistry Triterpenes - pharmacology Triterpenes - therapeutic use |
| title | Celastrol as a pentacyclic triterpenoid with chemopreventive properties |
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