Prenylated indole alkaloids from co-culture of marine-derived fungi Aspergillus sulphureus and Isaria felina
Five new prenylated indole alkaloids, 17-hydroxynotoamide D ( 1 ), 17- O -ethylnotoamide M ( 2 ), 10- O -acetylsclerotiamide ( 3 ), 10- O -ethylsclerotiamide ( 4 ), and 10- O -ethylnotoamide R ( 5 ) were isolated from a co-culture of marine-derived fungi Aspergillus sulphureus KMM 4640 and Isaria fe...
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| Veröffentlicht in: | Journal of antibiotics 2018-10, Vol.71 (10), p.846-853 |
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| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Five new prenylated indole alkaloids, 17-hydroxynotoamide D (
1
), 17-
O
-ethylnotoamide M (
2
), 10-
O
-acetylsclerotiamide (
3
), 10-
O
-ethylsclerotiamide (
4
), and 10-
O
-ethylnotoamide R (
5
) were isolated from a co-culture of marine-derived fungi
Aspergillus sulphureus
KMM 4640 and
Isaria felina
KMM 4639. The structures of
1
−
5
were determined by detailed analysis of spectroscopic data and by comparison with related known compounds. The absolute configurations of
1
−
5
were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Compound
2
is able to inhibit the colony formation of human prostate cancer cells 22Rv1 at non-cytotoxic concentration of 10 μM. |
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| ISSN: | 0021-8820 1881-1469 |
| DOI: | 10.1038/s41429-018-0072-9 |