Involvement of E2F transcription factor family in cancer

The E2F family of transcription factors is a central modulator of important cellular events, including cell cycle progression, apoptosis and DNA damage response. The role of E2F family members in various human malignancies is yet unclear and may provide vital clues to the diagnosis, prognosis and th...

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Veröffentlicht in:	European journal of cancer (1990) 2005-11, Vol.41 (16), p.2403-2414
Hauptverfasser:	Tsantoulis, P.K., Gorgoulis, V.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bladder tumours Breast tumours Cancer Cell Cycle Cell Line, Tumor DNA damage DNA Damage - genetics E2F transcription factors E2F Transcription Factors - genetics E2F1 transcription factor Genomic Instability - genetics Humans Lung cancer Mice Neoplasms - genetics Transcription factors
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Beschreibung
Zusammenfassung:	The E2F family of transcription factors is a central modulator of important cellular events, including cell cycle progression, apoptosis and DNA damage response. The role of E2F family members in various human malignancies is yet unclear and may provide vital clues to the diagnosis, prognosis and therapy of cancer patients. In this review we provide a brief but concise overview of E2F function and its putative role in the most common human tumour types.
ISSN:	0959-8049 1879-0852
DOI:	10.1016/j.ejca.2005.08.005