Attenuation of morphine withdrawal signs by a D1 receptor agonist in the locus coeruleus of rats

In the present study, the effects of intra-locus coeruleus injection of a dopamine D1 receptor agonist (SKF38393) on naloxone-induced withdrawal signs of morphine-dependent rats were examined. Twenty different withdrawal signs were assessed. The total withdrawal score was calculated and used as an i...

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Veröffentlicht in:	Neuroreport 2005-10, Vol.16 (15), p.1683-1686
Hauptverfasser:	Dizgah, Iraj Mirzaii, Karimian, Seyed Morteza, Zarrindast, Mohammad Reza, Sohanaki, Hamid
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - administration & dosage 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - antagonists & inhibitors 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - therapeutic use Animals Behavior, Animal - drug effects Benzazepines - administration & dosage Benzazepines - pharmacology Biological and medical sciences Dopamine Agonists - administration & dosage Dopamine Agonists - therapeutic use Drug addictions Injections Locus Coeruleus - physiology Male Medical sciences Morphine Dependence Naloxone - administration & dosage Naloxone - pharmacology Narcotic Antagonists - administration & dosage Narcotic Antagonists - pharmacology Rats Rats, Wistar Receptors, Dopamine D1 - agonists Receptors, Dopamine D1 - antagonists & inhibitors Substance Withdrawal Syndrome - drug therapy Toxicology
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Zusammenfassung:	In the present study, the effects of intra-locus coeruleus injection of a dopamine D1 receptor agonist (SKF38393) on naloxone-induced withdrawal signs of morphine-dependent rats were examined. Twenty different withdrawal signs were assessed. The total withdrawal score was calculated and used as an index of withdrawal intensity for comparison. The D1 agonist and antagonist were injected 15 and 30 min prior to expression of naloxone-induced withdrawal signs, respectively. SKF38393 (2 and 4 μg/site) decreased while SCH23390 (a D1 antagonist) had no effect on the total withdrawal score. On the other hand, SCH23390 (25 ng/site) reversed the SKF38393 effect. It may be concluded that activation of dopamine D1 receptors in the locus coeruleus attenuates naloxone-induced withdrawal.
ISSN:	0959-4965 1473-558X
DOI:	10.1097/01.wnr.0000180142.91644.65