Strength in numbers—an arrestin interaction code

Activation signals from GPCRs, the largest receptor family, are transmitted to heterotrimeric G proteins and arrestins, and can be differentially modulated by GPCR phosphorylation. In a recent article, available data, including multiple arrestin structures, are analyzed to decipher common and state-...

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Veröffentlicht in:	Nature structural & molecular biology 2018-06, Vol.25 (6), p.437-439
Hauptverfasser:	Draper-Joyce, Christopher J., Christopoulos, Arthur
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114 631/45/612/194 631/535 631/80/458/1733 Arrestin Arrestin - chemistry Arrestin - metabolism Arrestins Biochemistry Biological Microscopy Biomedical and Life Sciences Cell receptors Cellular signal transduction Composition Drug discovery G protein-coupled receptors G proteins Genomics Health aspects Heterotrimeric GTP-Binding Proteins - metabolism Hormones Human genome Humans Life Sciences Lipids Membrane Biology Membrane proteins News & Views news-and-views Phosphorylation Physiological aspects Protein Conformation Protein Structure Proteins Receptors, G-Protein-Coupled - metabolism Signal Transduction Statistics Structure
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Beschreibung
Zusammenfassung:	Activation signals from GPCRs, the largest receptor family, are transmitted to heterotrimeric G proteins and arrestins, and can be differentially modulated by GPCR phosphorylation. In a recent article, available data, including multiple arrestin structures, are analyzed to decipher common and state-specific conformational changes in arrestins and how these depend on patterns of receptor phosphorylation.
ISSN:	1545-9993 1545-9985
DOI:	10.1038/s41594-018-0077-x