Application of astatine-210: Evaluation of astatine distribution and effect of pre-injected iodide in whole body of normal rats

We proposed use of astatine-210 in preclinical study. Astatine-210 has higher yield of production and is easier to quantify than astatine-211. We produced astatine-210 with Bi target and 40 MeV alpha beam accelerated by cyclotron, free astatine-210 was separated and injected to normal rats. Three male rats (blocking group) were injected non-radioactive iodide before injection of astatine-210. Compared with the control group, the astatine-210 accumulations in the blocking group decreased to 24% in the thyroid. •Free 210At was administered to normal rats instead of free 211At.•The pre-injection of I- reduced the accumulation of 210At in the thyroid and stomach.•We estimated the behavior of 211At based on the biodistribution of 210At.