Diastereoselective addition of anisoles to N-tert-butanesulfinyl imines via four-membered lithium cycles

Diastereoselective addition of anisoles to N-tert-butanesulfinyl imines via four-membered lithium cycles

A highly regio- and diastereo-selective ortho-lithiation/addition of anisoles to N-tert-butanesulfinyl imines resulting in the selective formation of chiral α-branched amines is described. This method is also efficient for highly regioselective benzylic lithiation of o-methylanisoles, followed by di...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (51), p.7007-7009
Hauptverfasser: Reddy, Leleti Rajender, Kotturi, Sharadsrikar, Waman, Yogesh, Patel, Chirag, Patwa, Aditya, Shenoy, Rajesh
Format: Artikel
Sprache:eng
Schlagworte:
Amines
Imines
Lithium
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Zusammenfassung:A highly regio- and diastereo-selective ortho-lithiation/addition of anisoles to N-tert-butanesulfinyl imines resulting in the selective formation of chiral α-branched amines is described. This method is also efficient for highly regioselective benzylic lithiation of o-methylanisoles, followed by diastereoselective addition to N-tert-butanesulfinyl imines.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc03764g