The expression of IMP3 in 366 cases with ovarian carcinoma of high grade serous, endometrioid and clear cell subtypes

The clear cell (CCC), high grade serous (HGSC) and endometrioid (EC) ovarian carcinomas share overlapping histological features. The oncogene IMP3 is implicated in CCC with an elusive utility in differential diagnosis. We collected 366 cases with ovarian primary carcinomas to detect IMP3, Napsin-A a...

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Veröffentlicht in:	Pathology, research and practice research and practice, 2018-08, Vol.214 (8), p.1087-1094
Hauptverfasser:	Lu, Linghui, Wang, Shunni, Zhu, Qin, Qu, Yuqing, Gu, Weiyong, Ning, Yan, Chen, Xiaochen, Wang, Yiqin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Clear Cell - pathology Area Under Curve Biomarkers, Tumor - analysis Carcinoma, Endometrioid - pathology Carcinoma, Ovarian Epithelial Cystadenocarcinoma, Serous - pathology Female HNF-1β Humans Immunocytochemistry IMP3 Napsin-A Neoplasms, Glandular and Epithelial - pathology Ovarian clear cell carcinoma Ovarian Neoplasms - pathology RNA-Binding Proteins - analysis RNA-Binding Proteins - biosynthesis ROC Curve Sensitivity and Specificity
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Zusammenfassung:	The clear cell (CCC), high grade serous (HGSC) and endometrioid (EC) ovarian carcinomas share overlapping histological features. The oncogene IMP3 is implicated in CCC with an elusive utility in differential diagnosis. We collected 366 cases with ovarian primary carcinomas to detect IMP3, Napsin-A and HNF-1β by immunochemistry. In 351 cases, the positive expression rate of IMP3 in CCC was significantly higher than that either in EC or HGSC (p
ISSN:	0344-0338 1618-0631
DOI:	10.1016/j.prp.2018.05.026