Two-Year Outcomes of Anticoagulation for Acute Ischemic Stroke With Nonvalvular Atrial Fibrillation　― SAMURAI-NVAF Study

Two-Year Outcomes of Anticoagulation for Acute Ischemic Stroke With Nonvalvular Atrial Fibrillation　― SAMURAI-NVAF Study

Background:We determined the 2-year long-term risk-benefit profile in patients with stroke or transient ischemic attack (TIA) receiving warfarin or direct oral anticoagulants (DOACs) for nonvalvular atrial fibrillation (NVAF) using a prospective, multicenter, observational registry in Japan.Methods ...

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Veröffentlicht in:Circulation Journal 2018/06/25, Vol.82(7), pp.1935-1942
Hauptverfasser: Yoshimura, Sohei, Koga, Masatoshi, Sato, Shoichiro, Todo, Kenichi, Yamagami, Hiroshi, Kumamoto, Masaya, Itabashi, Ryo, Terasaki, Tadashi, Kimura, Kazumi, Yagita, Yoshiki, Shiokawa, Yoshiaki, Kamiyama, Kenji, Okuda, Satoshi, Okada, Yasushi, Takizawa, Shunya, Hasegawa, Yasuhiro, Kameda, Tomoaki, Shibuya, Satoshi, Nagakane, Yoshinari, Ito, Yasuhiro, Matsuoka, Hideki, Takamatsu, Kazuhiro, Nishiyama, Kazutoshi, Fujita, Kyohei, Kamimura, Teppei, Ando, Daisuke, Ide, Toshihiro, Yoshimoto, Takeshi, Shiozawa, Masayuki, Matsubara, Soichiro, Yamaguchi, Yoshitaka, Kinoshita, Naoto, Matsuki, Takayuki, Takasugi, Junji, Tokunaga, Keisuke, Higashida, Kyoko, Homma, Kazunari, Kario, Kazuomi, Arihiro, Shoji, Toyoda, Kazunori, for the SAMURAI Study Investigators
Format: Artikel
Sprache:eng
Schlagworte:
Acute stroke
Administration, Oral
Aged
Aged, 80 and over
Anticoagulants - administration & dosage
Anticoagulants - adverse effects
Anticoagulants - therapeutic use
Atrial fibrillation
Atrial Fibrillation - drug therapy
Brain Ischemia - chemically induced
Direct oral anticoagulants
Female
Follow-Up Studies
Humans
Infections - chemically induced
Intracranial hemorrhage
Ischemic Attack, Transient - drug therapy
Japan
Male
Middle Aged
Prospective Studies
Registries
Stroke - drug therapy
Survival Analysis
Treatment Outcome
Warfarin
Warfarin - adverse effects
Warfarin - therapeutic use
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Zusammenfassung:Background:We determined the 2-year long-term risk-benefit profile in patients with stroke or transient ischemic attack (TIA) receiving warfarin or direct oral anticoagulants (DOACs) for nonvalvular atrial fibrillation (NVAF) using a prospective, multicenter, observational registry in Japan.Methods and Results:NVAF patients within 7 days after onset of ischemic stroke/TIA were enrolled in 18 stroke centers. Outcome measures included ischemic and bleeding events and death in the 2-year follow-up period. We enrolled 1,116 patients taking either warfarin (650 patients) or DOACs (466 patients) at acute hospital discharge. DOAC users were younger and had lower National Institutes of Health Stroke Scale, CHADS2and discharge modified Rankin Scale scores than warfarin users (P
ISSN:1346-9843
1347-4820
1347-4820
DOI:10.1253/circj.CJ-18-0067