Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human [beta]-Cells and Adipose Tissue and Strong Association With Type 2 Diabetes

Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human [beta]-Cells and Adipose Tissue and Strong Association With Type 2 Diabetes

Recently, the transcription factor 7-like 2 (TCF7L2) gene has been associated with type 2 diabetes in subjects of European origin in the DeCode study. We genotyped the two most associated variants (rs7903146 and rs12255372) in 2,367 French type 2 diabetic subjects and in 2,499 control subjects. Both...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2006-10, Vol.55 (10), p.2903-2908
Hauptverfasser: Cauchi, Stéphane, Meyre, David, Christian, Dina, Choquet, Hélène
Format: Artikel
Sprache:eng
Schlagworte:
Body fat
Cardiovascular disease
Cholesterol
Chromosomes
Diabetes
Genes
Glucagon
Glucose
Homeostasis
Polymorphism
Transcription factors
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Zusammenfassung:Recently, the transcription factor 7-like 2 (TCF7L2) gene has been associated with type 2 diabetes in subjects of European origin in the DeCode study. We genotyped the two most associated variants (rs7903146 and rs12255372) in 2,367 French type 2 diabetic subjects and in 2,499 control subjects. Both the T-allele of rs7903146 and the T-allele of rs12255372 significantly increase type 2 diabetes risk with an allelic odds ratio (OR) of 1.69 (95% CI 1.55-1.83) (P = 6.0 x 10(-35)) and 1.60 (1.47-1.74) (P = 7.6 x 10(-28)), respectively. In nonobese type 2 diabetic subjects (BMI
ISSN:0012-1797
1939-327X