ARHGAP21 as a master regulator of multiple cellular processes
The cellular cytoskeleton is involved with multiple biological processes and is tightly regulated by multiple proteins and effectors. Among these, the RhoGTPases family is one of the most important players. RhoGTPAses are, in turn, regulated by many other elements. In the past decade, one of those r...
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| Veröffentlicht in: | Journal of cellular physiology 2018-11, Vol.233 (11), p.8477-8481 |
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| container_end_page | 8481 |
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| container_issue | 11 |
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| container_title | Journal of cellular physiology |
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| creator | Rosa, Lucas R. O. Soares, Gabriela M. Silveira, Leonardo R. Boschero, Antonio C. Barbosa‐Sampaio, Helena C. L. |
| description | The cellular cytoskeleton is involved with multiple biological processes and is tightly regulated by multiple proteins and effectors. Among these, the RhoGTPases family is one of the most important players. RhoGTPAses are, in turn, regulated by many other elements. In the past decade, one of those regulators, the RhoGAP Rho GTPase Activating Protein 21 (ARHGAP21), has been overlooked, despite being implied as having an important role on many of those processes. In this paper, we aimed to review the available literature regarding ARHGAP21 to highlight its importance and the mechanisms of action that have been found so far for this still unknown protein involved with cell adhesion, migration, Golgi regulation, cell trafficking, and even insulin secretion.
ARHGAP21 is an understudied but important protein related to multiple processes, especially those linked with the actin cytoskeleton, including migration, adhesion, intracellular transport, and insulin secretion. This review intends to summarize the known data regarding ARHGAP21’s role in those processes. |
| doi_str_mv | 10.1002/jcp.26829 |
| format | Article |
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ARHGAP21 is an understudied but important protein related to multiple processes, especially those linked with the actin cytoskeleton, including migration, adhesion, intracellular transport, and insulin secretion. This review intends to summarize the known data regarding ARHGAP21’s role in those processes.</description><subject>ARHGAP21</subject><subject>Biological activity</subject><subject>Cell adhesion</subject><subject>Cell adhesion & migration</subject><subject>cell dynamics</subject><subject>Cell migration</subject><subject>Cytoskeleton</subject><subject>Golgi cells</subject><subject>Guanosine triphosphatases</subject><subject>Insulin</subject><subject>Insulin secretion</subject><subject>Literature reviews</subject><subject>membrane trafficking</subject><subject>Proteins</subject><subject>Regulators</subject><subject>Secretion</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kMFLwzAUxoMobk4P_gMS8KKHbkmatH0HD2PopgwcoueQJql0tOtMWmT_vZmdHgRPD9778b3v-xC6pGRMCWGTtd6OWZIxOEJDSiCNeCLYMRqGG41AcDpAZ96vCSEAcXyKBgwykXAQQ3Q3fVnMpytGsfJY4Vr51jrs7HtXqbZxuClw3VVtua0s1raqwtrhrWu09d76c3RSqMrbi8McobeH-9fZIlo-zx9n02WkOQWIAArNC8MsUJ2nRmsNlFNDYmNiECbNRaZyHVOtDWRWsSJhWqcFsSazLNMsHqGbXjd8_uisb2Vd-r0dtbFN5yUjIYzgHPbo9R903XRuE9xJRinPBAvJA3XbU9o13jtbyK0ra-V2khK571SGTuV3p4G9Oih2eW3NL_lTYgAmPfBZVnb3v5J8mq16yS80XX9Y</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Rosa, Lucas R. O.</creator><creator>Soares, Gabriela M.</creator><creator>Silveira, Leonardo R.</creator><creator>Boschero, Antonio C.</creator><creator>Barbosa‐Sampaio, Helena C. L.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5244-889X</orcidid></search><sort><creationdate>201811</creationdate><title>ARHGAP21 as a master regulator of multiple cellular processes</title><author>Rosa, Lucas R. O. ; Soares, Gabriela M. ; Silveira, Leonardo R. ; Boschero, Antonio C. ; Barbosa‐Sampaio, Helena C. 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O.</creatorcontrib><creatorcontrib>Soares, Gabriela M.</creatorcontrib><creatorcontrib>Silveira, Leonardo R.</creatorcontrib><creatorcontrib>Boschero, Antonio C.</creatorcontrib><creatorcontrib>Barbosa‐Sampaio, Helena C. L.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosa, Lucas R. O.</au><au>Soares, Gabriela M.</au><au>Silveira, Leonardo R.</au><au>Boschero, Antonio C.</au><au>Barbosa‐Sampaio, Helena C. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ARHGAP21 as a master regulator of multiple cellular processes</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2018-11</date><risdate>2018</risdate><volume>233</volume><issue>11</issue><spage>8477</spage><epage>8481</epage><pages>8477-8481</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>The cellular cytoskeleton is involved with multiple biological processes and is tightly regulated by multiple proteins and effectors. Among these, the RhoGTPases family is one of the most important players. RhoGTPAses are, in turn, regulated by many other elements. In the past decade, one of those regulators, the RhoGAP Rho GTPase Activating Protein 21 (ARHGAP21), has been overlooked, despite being implied as having an important role on many of those processes. In this paper, we aimed to review the available literature regarding ARHGAP21 to highlight its importance and the mechanisms of action that have been found so far for this still unknown protein involved with cell adhesion, migration, Golgi regulation, cell trafficking, and even insulin secretion.
ARHGAP21 is an understudied but important protein related to multiple processes, especially those linked with the actin cytoskeleton, including migration, adhesion, intracellular transport, and insulin secretion. This review intends to summarize the known data regarding ARHGAP21’s role in those processes.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29856495</pmid><doi>10.1002/jcp.26829</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-5244-889X</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | ARHGAP21 Biological activity Cell adhesion Cell adhesion & migration cell dynamics Cell migration Cytoskeleton Golgi cells Guanosine triphosphatases Insulin Insulin secretion Literature reviews membrane trafficking Proteins Regulators Secretion |
| title | ARHGAP21 as a master regulator of multiple cellular processes |
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