ARHGAP21 as a master regulator of multiple cellular processes

The cellular cytoskeleton is involved with multiple biological processes and is tightly regulated by multiple proteins and effectors. Among these, the RhoGTPases family is one of the most important players. RhoGTPAses are, in turn, regulated by many other elements. In the past decade, one of those regulators, the RhoGAP Rho GTPase Activating Protein 21 (ARHGAP21), has been overlooked, despite being implied as having an important role on many of those processes. In this paper, we aimed to review the available literature regarding ARHGAP21 to highlight its importance and the mechanisms of action that have been found so far for this still unknown protein involved with cell adhesion, migration, Golgi regulation, cell trafficking, and even insulin secretion. ARHGAP21 is an understudied but important protein related to multiple processes, especially those linked with the actin cytoskeleton, including migration, adhesion, intracellular transport, and insulin secretion. This review intends to summarize the known data regarding ARHGAP21’s role in those processes.