Myalgia and cramps associated with zolmitriptan

To report a patient with myalgia and cramps possibly induced by the antimigrainous agent zolmitriptan. A 27-year-old woman with episodes of common migraine developed cramps and generalized myalgia after the use of intranasal zolmitriptan 5 mg to treat 3 episodes of migraine. This side effect had not occurred with oral zolmitriptan 2.5 mg. Myalgia and cramps should be considered a possible dose-dependent adverse effect of zolmitriptan.