Inside Cover: Multiplication of Human Natural Killer Cells by Nanosized Phosphonate-Capped Dendrimers (Angew. Chem. Int. Ed. 14/2007)

Inside Cover: Multiplication of Human Natural Killer Cells by Nanosized Phosphonate-Capped Dendrimers (Angew. Chem. Int. Ed. 14/2007)

Human peripheral blood mononuclear cells (white blood cells) cultured in the presence of dendrimers capped with phosphonate groups reveal a selective multiplication of natural killer (NK) cells. In their Communication on page 2523 ff., A.‐M. Caminade, R. Poupot, J.‐P. Majoral, and co‐workers describ...

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Veröffentlicht in:Angewandte Chemie International Edition 2007-03, Vol.46 (14), p.2334-2334
Hauptverfasser: Griffe, Laurent, Poupot, Mary, Marchand, Patrice, Maraval, Alexandrine, Turrin, Cédric-Olivier, Rolland, Olivier, Métivier, Pascal, Bacquet, Gérard, Fournié, Jean-Jacques, Caminade, Anne-Marie, Poupot, Rémy, Majoral, Jean-Pierre
Format: Artikel
Sprache:eng
Schlagworte:
biological activity
dendrimers
immunology
NK cells
phosphonates
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Zusammenfassung:Human peripheral blood mononuclear cells (white blood cells) cultured in the presence of dendrimers capped with phosphonate groups reveal a selective multiplication of natural killer (NK) cells. In their Communication on page 2523 ff., A.‐M. Caminade, R. Poupot, J.‐P. Majoral, and co‐workers describe the synthesis of various phosphazene dendrimers and their effect on NK cells, which play a key role in anticancer immunity. The picture shows a fluorescence microscopy image of a NK cell (red) engaged with target cancer cells (green).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200790051