Viridenepoxydiol, a New Pentasubstituted Oxiranyldecene Produced by Trichoderma viride

A new pentasubstituted oxiranyldecene, named viridenepoxydiol, has been isolated (0.9 mg/L) from the culture filtrate of a strain of Trichoderma viride showing in vitro and in vivo antagonistic activity against Sclerotium rolfsii, which is the causal agent of crown and stem rot of artichoke. Viridenepoxydiol was characterized as 3,5,9-trimethyl-2-oxiranyl-dec-8-ene-2,5-diol (3) using spectroscopic methods. It showed inhibitor effect on mycelial growth of S. rolfsii and its minimum inhibitory concentration (over 90% inhibition) was found to be 396 μg/mL. This is the first time that viridenepoxydiol was reported. Keywords: Trichoderma viride; oxiranyldecene; viridenepoxydiol; antifungal activity; Sclerotium rolfsii; biocontrol