Co-exposure of the Mycotoxins Lolitrem B and Ergovaline in Steers Fed Perennial Ryegrass (Lolium perenne) Straw: Metabolic Characterization of Excreta

Past research showed a strong linear correlation between levels of the mycotoxins lolitrem B (LB, a tremorgen) and ergovaline (EV, an ergot alkaloid and potent vasoconstrictor) in perennial ryegrass (PRG) forage. The purpose of this study was to characterize the excretion of these two compounds in b...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2018-06, Vol.66 (25), p.6394-6401
Hauptverfasser:	Murty, Lia D, Duringer, Jennifer M, Craig, A. Morrie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Feed - analysis Animal Feed - microbiology Animals Cattle - metabolism Cattle - urine Ergotamines - analysis Ergotamines - metabolism Ergotamines - urine Feces - chemistry Food Contamination - analysis Indole Alkaloids - analysis Indole Alkaloids - metabolism Indole Alkaloids - urine Lolium - chemistry Lolium - metabolism Lolium - microbiology Mycotoxins - analysis Mycotoxins - metabolism Mycotoxins - urine Urine - chemistry
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Beschreibung
Zusammenfassung:	Past research showed a strong linear correlation between levels of the mycotoxins lolitrem B (LB, a tremorgen) and ergovaline (EV, an ergot alkaloid and potent vasoconstrictor) in perennial ryegrass (PRG) forage. The purpose of this study was to characterize the excretion of these two compounds in beef cattle consuming PRG straw and to utilize liquid chromatography–tandem mass spectrometry to investigate the metabolism of LB and EV in excreta. Four groups of steers (n = 6/group) were fed endophyte-infected PRG for 64 days (2256/638, 1554/373, 1012/259, or 247/
ISSN:	0021-8561 1520-5118
DOI:	10.1021/acs.jafc.8b00963