The p21-activated kinase 4-Slug transcription factor axis promotes epithelial−mesenchymal transition and worsens prognosis in prostate cancer

Epithelial−mesenchymal transition (EMT) facilitates cancer invasion and metastasis and thus accelerates cancer progression. p21-activated kinase 4 (PAK4) is a critical regulator of prostate cancer (PC) progression. Here, we report that PAK4 activation promotes PC progression through the EMT regulato...

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Veröffentlicht in:	Oncogene 2018-09, Vol.37 (38), p.5147-5159
Hauptverfasser:	Park, Jung-Jin, Park, Mee-Hee, Oh, Eun Hye, Soung, Nak-Kyun, Lee, Soo Jae, Jung, Jae-Kyung, Lee, Ok-Jun, Yun, Seok Joong, Kim, Wun-Jae, Shin, Eun-Young, Kim, Eung-Gook
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/105 13/109 13/44 13/89 14 38 42 631/67/322 631/67/395 82 Antigens Apoptosis Bone morphogenetic proteins Cancer metastasis Care and treatment Cell Biology Development and progression E-cadherin Gene expression Genetic aspects Health aspects Human Genetics Immunohistochemistry Internal Medicine Medical schools Medicine Medicine & Public Health Mesenchyme Metastases Metastasis Oncology p21-activated kinase Pheochromocytoma cells Phosphotransferases Prostate cancer Stem cells Transcription factors Transforming growth factors Tumors
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Zusammenfassung:	Epithelial−mesenchymal transition (EMT) facilitates cancer invasion and metastasis and thus accelerates cancer progression. p21-activated kinase 4 (PAK4) is a critical regulator of prostate cancer (PC) progression. Here, we report that PAK4 activation promotes PC progression through the EMT regulator Slug. We find that phosphorylated PAK4 S474 (pPAK4) levels, an index of PAK4 activation, were tightly associated with Gleason score ( p
ISSN:	0950-9232 1476-5594
DOI:	10.1038/s41388-018-0327-8