Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease

We evaluate pregnancy outcome and anticoagulation regimes in women with mechanical and biological prosthetic heart valves (PHV) for congenital heart disease. Retrospective multicenter cohort studying pregnancy outcomes in an existing cohort of patients with PHV. 52 women had 102 pregnancies of which 78 pregnancies (46 women) ≥20 weeks duration (59 biological, 19 mechanical PHV). Miscarriages (n = 19, ≤20 weeks) occurred more frequently in women using anticoagulation (P