Low-Hanging Fruit and Antioxidant Therapy in Cystic Fibrosis

[...]oxidants are essential to allow oxidative killing of bacteria by neutrophils and macrophages. Individuals with the genetic disease known as chronic granulomatous disease are deficient in NADPH oxidase, a complex involved in oxidant synthesis by phagocytes, and manifest recurrent infections with Staphylococcus aureus, Burkholderia cepacia, and Aspergillus fumigatus, all of which are significant pathogens in CF (8). [...]with other currently available therapies proven to reduce pulmonary exacerbations such as inhaled antibiotics and CFTR (cystic fibrosis transmembrane conductance regulator) modulator therapy, the cost of antioxidant-supplemented multivitamin therapy is likely to be relatively modest, and can easily be added to current therapeutic regimens.