Cytotoxicity of cycloartane triterpenoids from aerial part of Cimicifuga foetida

Our previous study had demonstrated cytotoxicity of EtOAc fraction from aerial part of Cimicifuga foetida on various cancer cell lines. In the present study, we investigated the cytotoxicity of five cycloartane triterpenoids isolated from the EtOAc fraction. Compounds ( 1,2,3) showed moderate cytoto...

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Veröffentlicht in:	Fitoterapia 2006, Vol.77 (1), p.39-42
Hauptverfasser:	Tian, Ze, Pan, Rui Le, Si, JianYong, Xiao, Pei Gen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Cimicifuga Cimicifuga - chemistry Cycloartanes Cytotoxicity General pharmacology Glycosides Hepatocytes - drug effects Lanosterol - analogs & derivatives Medical sciences Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Components, Aerial - chemistry Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - toxicity Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - toxicity
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Zusammenfassung:	Our previous study had demonstrated cytotoxicity of EtOAc fraction from aerial part of Cimicifuga foetida on various cancer cell lines. In the present study, we investigated the cytotoxicity of five cycloartane triterpenoids isolated from the EtOAc fraction. Compounds ( 1,2,3) showed moderate cytotoxic activity on R-HepG2 cells and drug resistant sub line R-HepG2 but exhibited less toxicity against primary cultured normal mouse hepatocytes. Compounds ( 4) and ( 5) were inactive on all tested cell lines.
ISSN:	0367-326X
DOI:	10.1016/j.fitote.2005.08.001