Toxicology and pharmacokinetics of 1-methyl- d-tryptophan: Absence of toxicity due to saturating absorption

1-methyl- d-tryptophan (D-1MT) reverses the immunosuppressive effect of indoleamine 2,3-dioxygenase (IDO), and it is currently being developed both as a vaccine adjuvant and as an immunotherapeutic agent for combination with chemotherapy. The present study examined the pharmacokinetics and toxicity...

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Veröffentlicht in:	Food and chemical toxicology 2008, Vol.46 (1), p.203-211
Hauptverfasser:	Jia, Lee, Schweikart, Karen, Tomaszewski, Joseph, Page, John G., Noker, Patricia E., Buhrow, Sarah A., Reid, Joel M., Ames, Matthew M., Munn, David H.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-methyl- d-tryptophan Administration, Oral Animals Area Under Curve Biological and medical sciences Blood Proteins - metabolism Calibration Dogs Half-Life Indoleamine 2,3-dioxygenase Injections, Intravenous Intestinal Absorption Male Medical sciences Mice No-Observed-Adverse-Effect Level Pharmacokinetics Protein Binding Rats Rats, Inbred F344 Rats, Inbred Lew Saturating absorption Tissue Distribution Toxicity Toxicology Tryptophan - analogs & derivatives Tryptophan - blood Tryptophan - pharmacokinetics Tryptophan - toxicity
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Zusammenfassung:	1-methyl- d-tryptophan (D-1MT) reverses the immunosuppressive effect of indoleamine 2,3-dioxygenase (IDO), and it is currently being developed both as a vaccine adjuvant and as an immunotherapeutic agent for combination with chemotherapy. The present study examined the pharmacokinetics and toxicity of D-1MT in preparation for clinical trials. Incubation of D-1MT in rat plasma for 24 h produced no significant degradation, with
ISSN:	0278-6915 1873-6351
DOI:	10.1016/j.fct.2007.07.017