Exploring Gold Catalysis in a 1,6-Conjugate Addition/Domino Electrophilic Cyclization Cascade: Synthesis of Cyclohepta[b]indoles

Exploring Gold Catalysis in a 1,6-Conjugate Addition/Domino Electrophilic Cyclization Cascade: Synthesis of Cyclohepta[b]indoles

An effective method for the construction of the structurally complex fused cyclohepta­[b]­indole core has been developed through an intermolecular 1,6-conjugate addition of indoles to 2-alkynyl p-quinone methides followed by an intramolecular electrophilic cyclization under oxophilic and alkynophili...

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Veröffentlicht in:Journal of organic chemistry 2018-08, Vol.83 (15), p.8615-8626
Hauptverfasser: Jadhav, Abhijeet S, Pankhade, Yogesh A, Vijaya Anand, Ramasamy
Format: Artikel
Sprache:eng
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Zusammenfassung:An effective method for the construction of the structurally complex fused cyclohepta­[b]­indole core has been developed through an intermolecular 1,6-conjugate addition of indoles to 2-alkynyl p-quinone methides followed by an intramolecular electrophilic cyclization under oxophilic and alkynophilic gold catalysis.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.8b00607