Diazinon toxicity affects histophysiological and biochemical parameters in rabbits

Diazinon is a widely used pesticide in agriculture. So, the current work aimed to investigate the effects of diazinon exposure on some physiological and biochemical parameters, as well as, histopathological changes and histochemical acetyl-cholinesterase activity (AChE). The red Baladi rabbits were...

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Veröffentlicht in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2007-11, Vol.59 (3), p.215-225
Hauptverfasser:	Yehia, Mona A.H., El-Banna, Sabah G., Okab, Aly B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-cholinesterase Acetylcholinesterase - metabolism Administration, Cutaneous Animals Biochemical parameters Biological and medical sciences Brain - drug effects Brain - metabolism Brain - pathology Clinical Chemistry Tests Cytochrome p-450 Cytochrome P-450 Enzyme System - metabolism Diazinon Diazinon - toxicity Dose-Response Relationship, Drug Glycogen Glycogen - metabolism Hematologic Tests Histochemistry Insecticides - toxicity Investigative techniques, diagnostic techniques (general aspects) Kidney - drug effects Kidney - metabolism Kidney - pathology Liver - drug effects Liver - metabolism Liver - pathology Male Medical sciences Microsomes, Liver - drug effects Microsomes, Liver - metabolism Organ Size - drug effects Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Physiological parameter Rabbits Skin Absorption
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Zusammenfassung:	Diazinon is a widely used pesticide in agriculture. So, the current work aimed to investigate the effects of diazinon exposure on some physiological and biochemical parameters, as well as, histopathological changes and histochemical acetyl-cholinesterase activity (AChE). The red Baladi rabbits were dipped into water (Control Group), diazinon at low concentrations of 0.6 mg diazinon low concentration (DLC) or high concentration of 3 mg diazinon high concentration (DHC) dissolved in 1 l of water for 10 s. Treatment was repeated after 10 days and animals were sacrificed between 0 and 21 days after the second treatment. Blood analysis revealed that Red blood cells (RBC's), hemoglobin (Hb) and plasma total protein (TP) were significantly decreased in both diazinon concentrations ( P
ISSN:	0940-2993 1618-1433
DOI:	10.1016/j.etp.2007.09.003