Thiol-ene click chemistry towards easy microarraying of half-antibodies

Thiol-ene click chemistry towards easy microarraying of half-antibodies

A UV light-induced thiol-ene coupling reaction (TEC) between half-antibodies (hIgG) and vinyl functionalized glass surfaces was run for biosensing in the microarray format. The accomplished performance improved that obtained with whole antibodies.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (48), p.6144-6147
Hauptverfasser: Alonso, Rafael, Jiménez-Meneses, Pilar, García-Rupérez, Jaime, Bañuls, María-José, Maquieira, Ángel
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Chemical synthesis
Immunoglobulins
Organic chemistry
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Beschreibung
Zusammenfassung:A UV light-induced thiol-ene coupling reaction (TEC) between half-antibodies (hIgG) and vinyl functionalized glass surfaces was run for biosensing in the microarray format. The accomplished performance improved that obtained with whole antibodies.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc01369a