Antiviral Triketone‐Phloroglucinol‐Monoterpene Adducts from Callistemon rigidus

Callistrilones F – K (1 – 6), six new triketone‐phloroglucinol‐monoterpene hybrids were isolated from the twigs and leaves of Callistemon rigidus. Their structures with absolute configurations were established by a combination analysis of NMR spectra, X‐ray diffraction, and electronic circular dichr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemistry & biodiversity 2018-07, Vol.15 (7), p.e1800172-n/a
Hauptverfasser:	Cao, Jia‐Qing, Wu, Yan, Zhong, Yuan‐Lin, Li, Ni‐Ping, Chen, Mu, Li, Man‐Mei, Ye, Wen‐Cai, Wang, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts antiviral activity Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Antiviral drugs Callistemon rigidus callistrilones F – K Circular dichroism Dichroism Dose-Response Relationship, Drug Herpes simplex Hybrids Ketones - chemistry Ketones - isolation & purification Ketones - pharmacology Microbial Sensitivity Tests Molecular Conformation Monoterpenes - chemistry Monoterpenes - isolation & purification Monoterpenes - pharmacology Myrtaceae - chemistry NMR Nuclear magnetic resonance Phloroglucinol Phloroglucinol - chemistry Phloroglucinol - isolation & purification Phloroglucinol - pharmacology phloroglucinol derivatives Simplexvirus - drug effects Stereoisomerism Structure-Activity Relationship Viruses X-ray diffraction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Callistrilones F – K (1 – 6), six new triketone‐phloroglucinol‐monoterpene hybrids were isolated from the twigs and leaves of Callistemon rigidus. Their structures with absolute configurations were established by a combination analysis of NMR spectra, X‐ray diffraction, and electronic circular dichroism (ECD) calculations. Compounds 3 and 4 exhibited moderate inhibitory activities against herpes simplex virus (HSV‐1) with IC50 values of 10.00 ± 2.50 and 12.50 ± 1.30 μm, respectively.
ISSN:	1612-1872 1612-1880
DOI:	10.1002/cbdv.201800172